My Settings

Cursor Size

    System Preferences > Universal Access > Mouse & Trackpad > Cursor Size

Set the size between 1/4 and 1/2 -- More than that may obscure text.

Keyboard

    System Preferences > Universal Access > Keyboard
        Sticky Keys ON
        Display pressed keys on screen
    Enable access for assistive devices

TinkerTool Choices     Download

    Finder
        Show selected path in window title
    Dock
        Add stack for recent items (applications or documents, etc.)
        Placement: Start position

Keep the Dock small.
Don't close indispensable applications.
HOME folder contains folders only.
Finder folders fill the screen.
Folders are normally in icon view.