System Preferences > Universal Access > Mouse & Trackpad > Cursor Size
Set the size between 1/4 and 1/2 -- More than that may obscure text.
System Preferences > Universal Access > Keyboard
Sticky Keys ON
Display pressed keys on screen
Enable access for assistive devices
TinkerTool Choices Download
Show selected path in window title
Add stack for recent items (applications or documents, etc.)
Placement: Start position
Keep the Dock small.
Don't close indispensable applications.
HOME folder contains folders only.
Finder folders fill the screen.
Folders are normally in icon view.